Muva nje, izikhondlakhondla zikagwayi ezimbili ezinkulu, i-PMI ne-BAT, zishicilele amaphepha ocwaningo kumajenali ezokwelapha aphezulu emhlabeni jikelele.Imiphumela yocwaningo ibonisa ukuthi imikhiqizo emisha kagwayi efana nogwayi we-elekthronikhi nokushisa okungashisi ayinabungozi futhi inobuthi kunogwayi wendabuko, futhi inganciphisa kakhulu umthelela ohlelweni lokuphefumula.umonakalo.
Njengoba ukuqwashisa kwabantu ngezingozi zokubhema kukhula, ugwayi we-elekthronikhi uya ngokuya uqashelwa ngumphakathi njengothatha indawo kagwayi.Nokho, umthelela yesikhathi eside enongiwei-e-cigaretteizingxube ze-flavour kanye nentuthu kagwayi kubantu ababhemayo kusazobhekwa kabanzi.
Muva nje, u-PMI uPhilip Morris International ushicilele umbiko wocwaningo "Ukuhlolwa kobuthi bokuphefumula kwentuthu kagwayi kanye nama-aerosols avela ezixubeni ze-flavour: isifundo seviki le-5 kumagundane we-A / J" ku-British Journal of Toxicology "Journal of Applied Toxicolog", echaza imininingwane. wezihloko ezihlobene Izinyathelo zocwaningo kanye nemiphumela.
Ocwaningweni, amagundane abesilisa angama-87 kanye namagundane angama-nulliparous nakhulelwe angama-174 abelwa amaqembu okuhlola ayi-9, futhi aqhutshwa emoyeni, intuthu kagwayi, nama-aerosol e-e-cigarette anezingxube ezintathu ezihlukene zama-flavour, aphezulu, aphakathi, naphansi.Ukuchayeka kufika emahoreni ayi-6 ngosuku, izinsuku ezi-5 ngeviki, amasonto ama-5 kwalandelwa i-necropsy, isisindo somzimba kanye nokuhlolwa kwe-histopathological.
Isithombe sibonisa idatha yokuhlola yokuvuvukala kwamaphaphu egundane.Kungabonakala ukuthi idatha efanele yamagundane achayeke entuthuni kagwayi inempendulo esobala kakhulu (ingxenye ebomvu)
Imiphumela yokugcina yokuhlola ibonise ukuthi lapho amagundane evezwa ama-aerosol e-e-cigarette anamakha nangenawo, uma kuqhathaniswa nalawo achayeka entuthuni kagwayi, azikho izinguquko eziphawulekayo ezithweni zokuphefumula, ikhala, nezicubu ze-laryngeal epithelial, ezibonisa ukuthi i-e-cigarettes. I-sol ayicasuli kancane izicubu nezitho ezihambisanayo.Imiphumela yokuhlolwa ifakazela futhi ukuthi, uma kuqhathaniswa nogwayi wendabuko,i-e-cigaretteskunganciphisa kakhulu ukuvuvukala kwamaphaphu, kanye nokulimala kwekhala, umphimbo kanye ne-tracheal epithelium.
I-BAT British American Tobacco ishicilele iphepha locwaningo elinesihloko esithi “An Experimental Analytical and In Vitro Approach to Bridge between Different Different Tobacco Product Variants” kujenali yesayensi “Iminikelo Yokucwaninga Ngogwayi NeNicotine”, futhi yenza ucwaningo ngeTHP (imikhiqizo ye-HNB) I-Toxicology. ukuhlola.
Ocwaningweni, ama-aerosol nentuthu kagwayi yezinhlobonhlobo ezinhlanu ze-THP kanye ne-THP eyodwa eyisisekelo kwasetshenziswa njengendawo yokuhlola, futhi i-cytotoxicity yahlolwa ngokusebenza kwamaseli e-epithelial yamaphaphu omuntu.Imiphumela yabonisa ukuthi konke ukusabela kwe-cytotoxic eqenjini le-THP bekucishe kube ngaphansi ngo-95% kunalezo eziseqenjini lentuthu kagwayi, futhi awukho umehluko obalulekile wobuthi phakathi kwama-THP amahlanu ahlukene kanye ne-THP eyisisekelo.
Ngokocwaningo, ukuthuthukiswa nokuhlinzekwa kweminye imikhiqizo kagwayi ne-nicotine kukhula ngokushesha, abathengi baya ngokuya bemukela imikhiqizo emisha efana ne-THP, futhi ukuphepha kwayo kanye nobungozi njengengxenye yokuhlola okunobuthi kufanele ukunakwa kwemboni.Kuphela uma umkhiqizo ufinyelela amazinga (okuhlanganisa nokusebenza kwebhethri) lapho ungadlala indima yawo enhle njengesu lezempilo lomphakathi.
Izithenjwa
Ee Tsin Wong, Karsta Luettich, Lydia Cammack, et al.Ukuhlolwa kobuthi bokuhogela bentuthu kagwayi nama-aerosol avela ezixubeni zokunambitheka: Ucwaningo lwamaviki angu-5 kumagundane e-A/J.Ijenali ye-toxicolog esetshenzisiwe, 2022
Tomasz Jaunky, David Thorne, Andrew Baxter, et al.Indlela Yokuhlola Yokuhlola kanye Ne-In Vitro Yebhuloho Phakathi Kwezinhlobonhlobo Ezihlukene Zomkhiqizo Kagwayi Oshisayo.Iminikelo Ocwaningweni lukagwayi ne-Nicotine, 2022
Isikhathi sokuthumela: Dec-16-2022
